RealGM

QB - Alex Smith
WR - Reggie Wayne
WR - Chad Johnson
WR - Jericho Cotchery
RB - Shaun Alexander
RB - Jamal Lewis
TE - Tony Gonzalez
WR/RB flex - currently have DeAngelo Williams
K - Olindo Mare
DEF - Denver
DL - A.J. Hawk
DL - Lofu Tatupu
DB - Ronde Barber
DB - DeAngelo Hall

Bench
QB - Jason Campbell
WR - Santonio Holmes
WR - Reggie Williams
RB - Leon Washington
TE - Greg Olsen
DL - Julius Peppers
DL - Andra Davis
DB - Dunta Robinson

~~
14 teams with individual defensive always turns out weird, but projected Yahoo, my team is best by a few points over all teams. I'm somewhat happy - QB is very weak, but hope Alex Smith will be a sleeper.

Should I start Holmes over Williams in the flex? I would suspect Williams won't be that great early in the season and Holmes has a good streak end of last year.

I'd start Williams.

I do agree you go with the back, but I really like the matchup Holmes has against Cleveland.

Cleveland has a very underrated secondary. Plus they're pretty good at pressuring QBs. Holmes may be a risky proposition. I'd go with Williams right now.