Luka Doncic missed the Los Angeles Lakers' 131-126 loss to the Denver Nuggets on Friday night with a left calf injury and sprained right ankle.
LeBron James, Rui Hachimura, and Jaxson Hayes had all previously left the Lakers' road trip early to receive treatment in Los Angeles.
Dorian Finney-Smith, Gabe Vincent, and Trey Jemison III were also out against the Nuggets.
The Lakers finished 0-4 on the road trip.