Only two players have thrown 500 touchdown passes in NFL history, but two more players will join the club very soon.
Peyton Manning (539) and Brett Favre (508) lead the all-time touchdown list.
Tom Brady enters Week 5 with 497 scoring passes, while Drew Brees is at 496.
Brady and the New England Patriots will face the Indianapolis Colts on Thursday night, while Brees and the New Orleans Saints will play the Washington Redskins on Monday night.