Jimmy Garoppolo has been ruled out for Week 5 against the San Francisco 49ers.
Trey Lance will start in place of Garoppolo, who suffered a calf contusion in Week 4.
The 49ers will play at the undefeated Arizona Cardinals.
Trey Lance To Start Week 5 With Jimmy Garoppolo Ruled Out
Trey Lance To Start Week 5 With Jimmy Garoppolo Ruled Out
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