Kurtz wrote:clyde21 wrote:babyjax13 wrote:1. it contributes to the development of variants
leaky vaccines are just as likely if not more likely to contribute to development of new and stronger variants.
https://www.healthline.com/health-news/leaky-vaccines-can-produce-stronger-versions-of-viruses-072715
Clyde...what in blue hell are you talking about? You don't trust this vaccine that's been tested on millions of people yet as a counter-argument you cite a study done on chickens, with a completely different virus?
Even then, did you bother thinking about what you've read in the study? Here's an excerpt from it:
"These vaccines also allow the virulent virus to continue evolving precisely because they allow the vaccinated individuals, and therefore themselves, to survive,” said Venugopal Nair, who led the research team. He is the head of the Avian Viral Diseases program at The Pirbright Institute."
He is saying that the virus evolves in vaccinated chickens because the unvaccinated ones **** die from it. How is that an argument against vaccination? Also how is that test with a different, deadlier virus at all relevant to COVID, which has a ~98% survival rate even amongst the unvaccinated?
Dude, it's straight-forward. The variants emerge when the virus replicates in the body. There is an infinitesimal chance of a variant mutation emerging during a replication, but give it trillions x trillions of replications and eventually variants will come out.
Vaccinated people have a smaller viral load. They also carry the virus for a shorter period of time. Thus mathematically, a virus carried by a vaccinated person has a much smaller amount of replication and the odds of a variant coming from a vaccinated person are thus proportionally lower compared to an unvaccinated one.
im not sure what chickens has to do with anything, all medical research is done on animals pretty much, some of the most cited papers in the world the research was done on mice and chickens and other animals...not sure why NOW you think that is beyond the pale.
here is the actual study:
There is a theoretical expectation that some types of vaccines could prompt the evolution of more virulent (“hotter”) pathogens. This idea follows from the notion that natural selection removes pathogen strains that are so “hot” that they kill their hosts and, therefore, themselves. Vaccines that let the hosts survive but do not prevent the spread of the pathogen relax this selection, allowing the evolution of hotter pathogens to occur. This type of vaccine is often called a leaky vaccine. When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist. This theory proved highly controversial when it was first proposed over a decade ago, but here we report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease. The future challenge is to identify whether there are other types of vaccines used in animals and humans that might also generate these evolutionary risks.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002198
aka the covid vaccine.
here is another from 2018:
Vaccines Are Pushing Pathogens to Evolve.
Just as antibiotics breed resistance in bacteria, vaccines can incite changes that enable diseases to escape their control. Researchers are working to head off the evolution of new threats.
https://www.quantamagazine.org/how-vaccines-can-drive-pathogens-to-evolve-20180510/
from Lancet in 2021:
Given that the antibody response to the spike protein is so focused, could mutations in these restricted sequences lead to a less efficacious vaccine, if the human immune response is specific to the vaccine sequence? These mutations might be driven by antigenic drift, or by selection, either during natural infection or due to the vaccine itself. When a virus is grown under the selective pressure of a single monoclonal antibody that targets a single epitope on a viral protein, mutations in that protein sequence will lead to the loss of neutralisation, and the generation of escape mutants. This sequence of events has been shown in the laboratory for polio, measles, and respiratory syncytial virus,7 and in 2020 for SARS-CoV-2.8
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00075-8/fulltext
should I keep going?