Coronavirus/COVID-19, Thread 2

[SuperDeluxe]

This video was shared by a doctor who is a contact of mine on LinkedIn. I can't really say if this is good advice or not, but thought I'd share anyway:

Watch on YouTube

[Parliament10]

Read on Twitter

Not looking good for the British Prime Minister.

[exculpatory]

This video was shared by a doctor who is a contact of mine on LinkedIn. I can't really say if this is good advice or not, but thought I'd share anyway:

Watch on YouTube

Any respiratory therapists who can comment on this?

Makes sense.

[exculpatory]

Read on Twitter

Not looking good for the British Prime Minister.

That likely means respiratory failure mandating intubation - or close to that.

Bad prognosis.

Who takes over the government? Edit - Dominic Raab?

[Parliament10]

Read on Twitter

Prince Charles, has recovered from COVID-19.

[Parliament10]

Read on Twitter

Not looking good for the British Prime Minister.

That likely means respiratory failure mandating intubation.

Bad prognosis.

Who takes over the government?

There is currently no Deputy Prime Minister, so the next highest in order, are.:
Chancellor of the Exchequer, Foreign Secretary and Home Secretary.


The UK does not have a clear emergency succession plan for its prime minister
By Hasit Shah | Deputy news editor | April 6, 2020

https://qz.com/1833606/uk-lacks-succession-plan-as-boris-johnson-battles-covid-19/

If a prime minister departs suddenly for any reason, the party to which they belong elects a new leader and, after confirmation by the Queen, that person becomes the new permanent prime minister. That process could take days, or even weeks.

In an emergency, like the one the UK is facing right now, the baton would most likely be passed first to one of the three most senior government ministers: the chancellor (finance minister), home secretary, or foreign secretary. But there is no written rule that states which of those three would take charge. Dominic Raab, the country’s foreign secretary, is now chairing government meetings while Johnson is sick.

This is really Not good.


Edit:
https://en.wikipedia.org/wiki/Cabinet_rank

When Boris Johnson assumed the premiership, he appointment (sic) Dominic Raab as First Secretary of State.

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[Parliament10]

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Read on Twitter

[SuperDeluxe]

"It sounds like he hasn't been incubated, which is obviously is a good thing."

Or intubated, which would obviously be bad news.

[Parliament10]

Watch on YouTube

[Slax]

If you want to know how your community is doing in terms of social distancing, you might want to take a look at Google's Community Mobility Reports: https://www.google.com/covid19/mobility/

Someone here in Quebec prepared a graph combining the parks and retail data for Canadian provinces and U.S. states: https://www.facebook.com/photo.php?fbid=10159662070678502&set=gm.2491468971114982&type=3&theater
(The information, which is from April 2. was taken from the Google reports I linked to above. Higher percentage is better.)

Can someone confirm that the Facebook image is visible?

Is this graph showing me how much people are moving, or how much LESS people are moving relative to the distances they moved, say, a month ago?

If it's just telling me that people in, say, Washington DC travel more miles per day than people in Arkansas, that's not helpful.

Based on my limited French, I believe it's showing % reduction in visits to places of business and entertainment.

[SuperDeluxe]

If you want to know how your community is doing in terms of social distancing, you might want to take a look at Google's Community Mobility Reports: https://www.google.com/covid19/mobility/

Someone here in Quebec prepared a graph combining the parks and retail data for Canadian provinces and U.S. states: https://www.facebook.com/photo.php?fbid=10159662070678502&set=gm.2491468971114982&type=3&theater
(The information, which is from April 2. was taken from the Google reports I linked to above. Higher percentage is better.)

Can someone confirm that the Facebook image is visible?

Is this graph showing me how much people are moving, or how much LESS people are moving relative to the distances they moved, say, a month ago?

If it's just telling me that people in, say, Washington DC travel more miles per day than people in Arkansas, that's not helpful.

Based on my limited French, I believe it's showing % reduction in visits to places of business and entertainment.

Exactly. It's how much less people are moving. This graph in particular represents how much less people are frequenting places of recreation and retail stores. So higher percentage means that more people are complying with social distancing.

EDIT: This is the exact description of what that graph covers: "Mobility trends for places like restaurants, cafes, shopping centers, theme parks, museums, libraries, and movie theaters."

Of note: all of this data is for April 2, the last day Google updated their info.

[Parliament10]

Read on Twitter

Read on Twitter

[K For Three]

The older man my folks knew who died of this virus has a wife who just tested positive too but she has very few symptoms and is in isolation. I don't know how serious her symptoms are but they prescribed her the antibiotic Levoflaxin 750 mg a day for a week for something she was experiencing.

I think the moral of the story is, you listen to the particular doctor you work with with these things right now if you have a problem.

Update.

This woman whose husband died of covid-19 does have it too but not with the symptoms as serious. She texts with my mom daily.

She has taken that antibiotic.

But she did have shortness of breath today and went to a clinic and talked to a pulmonary doctor today who told her to get ZINC to take everyday too.

ZINC can help kill the virus.

This woman is a former nurse btw.

I have a big bottle but gave a lot of it to my folks to take one everyday now. At the very least, zinc won't hurt you.

Just passing along info I heard.

[Parliament10]

The older man my folks knew who died of this virus has a wife who just tested positive too but she has very few symptoms and is in isolation. I don't know how serious her symptoms are but they prescribed her the antibiotic Levoflaxin 750 mg a day for a week for something she was experiencing.

I think the moral of the story is, you listen to the particular doctor you work with with these things right now if you have a problem.

Update.

This woman whose husband died of covid-19 does have it too but not with the symptoms as serious. She texts with my mom daily.

She has taken that antibiotic.

But she did have shortness of breath today and went to a clinic and talked to a pulmonary doctor today who told her to get ZINC to take everyday too.

ZINC can help kill the virus.

This woman is a former nurse btw.

I have a big bottle but gave a lot of it to my folks to take one everyday now. At the very least, zinc won't hurt you.

Just passing along info I heard.

IDK if Zinc "kills" it. But it's usually used to keep a cold/flu from reproducing.

[K For Three]

The older man my folks knew who died of this virus has a wife who just tested positive too but she has very few symptoms and is in isolation. I don't know how serious her symptoms are but they prescribed her the antibiotic Levoflaxin 750 mg a day for a week for something she was experiencing.

I think the moral of the story is, you listen to the particular doctor you work with with these things right now if you have a problem.

Update.

This woman whose husband died of covid-19 does have it too but not with the symptoms as serious. She texts with my mom daily.

She has taken that antibiotic.

But she did have shortness of breath today and went to a clinic and talked to a pulmonary doctor today who told her to get ZINC to take everyday too.

ZINC can help kill the virus.

This woman is a former nurse btw.

I have a big bottle but gave a lot of it to my folks to take one everyday now. At the very least, zinc won't hurt you.

Just passing along info I heard.

IDK if Zinc "kills" it. But it's usually used to keep a cold/flu from reproducing.

I was sort of exaggerating lol. but I have heard around here some promising stuff on Zinc. It can help a lot with illnesses and hey if doctors suggest it at times in Mass thats good enough for me.

[Parliament10]

Read on Twitter

[Parliament10]

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This is interesting.

[threrf23]

Zinc is oft claimed to boost the immune system, so it makes sense that it could help, in theory. My mom has tried to push Zinc and Echinacea and stuff on me in the past, but none of that stuff seems to do anything for me.

This is an interesting report from a Chinese hospital that treated 104 gravely ill patients. None of their patients died. It seems to cover various subjects ranging from pharmaceuticals, traditional Chinese Medicine, and probiotics. The link above merely provides the abstract, but a more detailed PDF can be found here

I am personally putting my money on Ivermectin as a likely treatment, if not cure. It has been shown in lab experiments to kill the SARS virus, not COVID-19 in particular as some have reported. But, I linked this 2017 piece from The Journal of Antibiotics the other day, and have been taking a closer look at it...

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo’s prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

The avermectins potentiate neurotransmission by disrupting glutamate-gated chloride channels, as well as having minor effects on γ-aminobutyric acid (GABA) receptors. They disrupt neurotransmission in nerve and muscle cells, causing hyperpolarisation of the neuronal membrane, inducing paralysis of somatic muscles, particularly the pharyngeal pump, killing the parasites. GABA-related channels are commonplace throughout nematodes and insects, whereas in mammals, GABA receptors and neurons are restricted to the central nervous system. Ivermectin is therefore very safe for vertebrates, as it cannot cross the blood–brain barrier. Adult filarial worms (macrofilariae), once paired, do not require substantial movement or pharyngeal pumping. Consequently, ivermectin treatment results in a rapid and almost total (98%) reduction in dermal-dwelling immature worms (microfilariae),30 but has only a limited sterilizing effect on female macrofilariae.31

A 2011 study investigated the impact of ivermectin on allergic asthma symptoms in mice and found that ivermectin (at 2 mg kg−1) significantly curtailed recruitment of immune cells, production of cytokines in the bronchoalveolar lavage fluids and secretion of ovalbumin-specific IgE and IgG1 in the serum. Ivermectin also suppressed mucus hypersecretion by goblet cells, establishing that ivermectin can effectively curb inflammation, such that it may be useful in treating allergic asthma and other inflammatory airway diseases.83

Recent research has confounded the belief, held for most of the past 40 years, that ivermectin was devoid of any antiviral characteristics. Ivermectin has been found to potently inhibit replication of the yellow fever virus, with EC50 values in the sub-nanomolar range. It also inhibits replication in several other flaviviruses, including dengue, Japanese encephalitis and tick-borne encephalitis, probably by targeting non-structural 3 helicase activity.97 Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral.98

Ivermectin has also been demonstrated to be a potent broad-spectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes. Ivermectin may be of import in disrupting HIV-1 integrase in HIV-1 as well as NS-5 (non-structural protein 5) polymerase in dengue viruses.99, 100

This Wuhan study, published March 31st, seems to support Trump's claims that hydroxychloroquine can help. Lots of people take hydroxychloroquine without bad side effects (provided they are obtaining medicine and not a fish tank cleaner), so as much as I think that Donald Trump is a little brat throwing tantrums without regard to the impact of his words, I think there is actually some substance to his rhetoric on this issue. I actually think he means well in this particular case.

I have purchased this, and should be receiving it on Thursday. Not that I want liability if anyone follows my advice, but I suspect that this stuff can help quite a bit against COVID and I would take it as a last resort if I was vulnerable and developed symptoms. I am going to start taking a small dosage even though I don't have symptoms, and will update to let you guys know that it didn't kill me (unless it does kill me, of course).

[Mr_Mojo_Risin]

Zinc is oft claimed to boost the immune system, so it makes sense that it could help, in theory. My mom has tried to push Zinc and Echinacea and stuff on me in the past, but none of that stuff seems to do anything for me.

This is an interesting report from a Chinese hospital that treated 104 gravely ill patients. None of their patients died. It seems to cover various subjects ranging from pharmaceuticals, traditional Chinese Medicine, and probiotics. The link above merely provides the abstract, but a more detailed PDF can be found here

I am personally putting my money on Ivermectin as a likely treatment, if not cure. It has been shown in lab experiments to kill the SARS virus, not COVID-19 in particular as some have reported. But, I linked this 2017 piece from The Journal of Antibiotics the other day, and have been taking a closer look at it...

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo’s prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

The avermectins potentiate neurotransmission by disrupting glutamate-gated chloride channels, as well as having minor effects on γ-aminobutyric acid (GABA) receptors. They disrupt neurotransmission in nerve and muscle cells, causing hyperpolarisation of the neuronal membrane, inducing paralysis of somatic muscles, particularly the pharyngeal pump, killing the parasites. GABA-related channels are commonplace throughout nematodes and insects, whereas in mammals, GABA receptors and neurons are restricted to the central nervous system. Ivermectin is therefore very safe for vertebrates, as it cannot cross the blood–brain barrier. Adult filarial worms (macrofilariae), once paired, do not require substantial movement or pharyngeal pumping. Consequently, ivermectin treatment results in a rapid and almost total (98%) reduction in dermal-dwelling immature worms (microfilariae),30 but has only a limited sterilizing effect on female macrofilariae.31

A 2011 study investigated the impact of ivermectin on allergic asthma symptoms in mice and found that ivermectin (at 2 mg kg−1) significantly curtailed recruitment of immune cells, production of cytokines in the bronchoalveolar lavage fluids and secretion of ovalbumin-specific IgE and IgG1 in the serum. Ivermectin also suppressed mucus hypersecretion by goblet cells, establishing that ivermectin can effectively curb inflammation, such that it may be useful in treating allergic asthma and other inflammatory airway diseases.83

Recent research has confounded the belief, held for most of the past 40 years, that ivermectin was devoid of any antiviral characteristics. Ivermectin has been found to potently inhibit replication of the yellow fever virus, with EC50 values in the sub-nanomolar range. It also inhibits replication in several other flaviviruses, including dengue, Japanese encephalitis and tick-borne encephalitis, probably by targeting non-structural 3 helicase activity.97 Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral.98

Ivermectin has also been demonstrated to be a potent broad-spectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes. Ivermectin may be of import in disrupting HIV-1 integrase in HIV-1 as well as NS-5 (non-structural protein 5) polymerase in dengue viruses.99, 100

This Wuhan study, published March 31st, seems to support Trump's claims that hydroxychloroquine can help. Lots of people take hydroxychloroquine without bad side effects (provided they are obtaining medicine and not a fish tank cleaner), so as much as I think that Donald Trump is a little brat throwing tantrums without regard to the impact of his words, I think there is actually some substance to his rhetoric on this issue. I actually think he means well in this particular case.

I have purchased this, and should be receiving it on Thursday. Not that I want liability if anyone follows my advice, but I suspect that this stuff can help quite a bit against COVID and I would take it as a last resort if I was vulnerable and developed symptoms. I am going to start taking a small dosage even though I don't have symptoms, and will update to let you guys know that it didn't kill me (unless it does kill me, of course).

Pretty sure it does kill SARS-Cov-2

https://www.monash.edu/news/articles/coronavirus-fight-possible-covid-19-drug-identified-by-scientists

[threrf23]

Pretty sure it does kill SARS-Cov-2

https://www.monash.edu/news/articles/coronavirus-fight-possible-covid-19-drug-identified-by-scientists

Yes, but it hasn't been shown to kill Covid-19. The Covid-19 part is speculation.