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Left-hander Jon Lester takes the mound in Anaheim for his fourth start of the season since returning to the Red Sox. It was at Angel Stadium where Lester made his last start before being diagnosed with treatable lymphoma last August.
As for any special significance in returning to Anaheim, Lester says there is none.

"I'm just looking at it as another start," he said. "I'm worried about that lineup."

That Angels lineup is one against which Lester will have need better command of his pitches than he did in his last outing, Friday.

"In Seattle, I didn't have really good command of the fastball on the outside of the plate," Lester said,. "I have to really do a better job of that against the kind of lineup I'll face."

While Lester denies that Wednesday's game will be anything other than just another game, and he says that he doesn't think about the past much, he did let on that next Tuesday's start in Fenway, his first since his illness, will be special.

"I'm sure the emotions will come back on Tuesday," he said. "I'm looking forward to pitching again in Fenway Park."

Pitching matchup

BOS: LHP Jon Lester (1-0, 5.09 ERA)
Lester was staked to a 3-0 lead early in his last outing, but couldn't get past the fifth inning in Seattle. He worked five innings, allowing four runs on eight hits before leaving with the game tied at 4. Lester also walked two and struck out four in the no-decision. After winning his first start, Lester has had a pair of no-decisions for the Red Sox.

LAA: RHP Dustin Moseley (4-1, 4.43 ERA)
Moseley survived some shaky innings and gave the Angels a good start in his last outing against Oakland. Moseley allowed three runs over 5 1/3 innings, as all three runs scored in the third inning. He allowed the first two hitters of the second to reach base but escaped that jam. He left in the sixth with the bases loaded and one out, and the bullpen helped him get out of that mess. He has faced Boston once in relief, dealing two scoreless innings.