Coronavirus/COVID-19

[captain green]

So when is China going to be held accountable for this?

Have they ever been accountable in there history?
They beheaded that dude that sold bunk dog food so maybe the behead a dr.

[Curmudgeon]

You can't blame China for having 1.4 billion people and being the perfect incubator for this kind of thing. Viruses mutate, that's just what they do.

What we need is a very well-funded group of medical researchers at the CDC (or elsewhere) that anticipates these mutations and learns how to create vaccines quickly. The trick is to stay one step ahead. We haven't.

[Bleeding Green]

Were they protesting in the Hubei? All those protestors eating bat soup and gorilla meat, 700 miles from where the protests were, making 15% the income of the average Hong Kong resident.

I mean, the Chinese government could have intended a small scale trial run.

Seems about as likely as Jamal Crawford being signed by the Celtics.

[watsonthedragon]

You can't blame China for having 1.4 billion people and being the perfect incubator for this kind of thing. Viruses mutate, that's just what they do.

What we need is a very well-funded group of medical researchers at the CDC (or elsewhere) that anticipates these mutations and learns how to create vaccines quickly. The trick is to stay one step ahead. We haven't.

Correct. We need to be proactive, not reactive. Hell, the US has barely even been reactive up to this point.

[GoCeltics123]

Read on Twitter

[GoCeltics123]

Read on Twitter

Lacob really once was a minority owner of the Celtics and is from Framingham. What a dick

[watsonthedragon]

President says coronavirus will 'go away' as pressure grows for economic relief | “It will go away. Just stay calm. It will go away,” “We want to protect our shipping industry, our cruise industry, cruise ships. We want to protect our airlines industry.”

[5InOfLouisville]

You can't blame China for having 1.4 billion people and being the perfect incubator for this kind of thing. Viruses mutate, that's just what they do.

What we need is a very well-funded group of medical researchers at the CDC (or elsewhere) that anticipates these mutations and learns how to create vaccines quickly. The trick is to stay one step ahead. We haven't.

Correct. We need to be proactive, not reactive. Hell, the US has barely even been reactive up to this point.

If theres one thing ive learned from modern politics, it’s that it is way easier to blame someone else and cling to the past than it is to self-reflect, behave rationally and be proactive.

And people hate ideas that arent easy.

[threrf23]

Seems about as likely as Jamal Crawford being signed by the Celtics.

Celtics’ Jaylen Brown: “I think Jamal Crawford can still play, I say let him go”

[Bleeding Green]

Seems about as likely as Jamal Crawford being signed by the Celtics.

Celtics’ Jaylen Brown: “I think Jamal Crawford can still play, I say let him go”

Jaylen Brown confirmed poster in the buyout thread. Also quoted later saying, "if Muggsy Bogues or Pete Maravich are still out there, I say sign them too."

[Parliament10]

Harvard, MIT move to online classes, ask students NOT to return after Spring Break


https://www.boston25news.com/news/harvard-moves-online-classes-due-coronavirus-students-asked-not-return-after-spring-break/FBF2XD2WJBAKBCBNLYBCIF6EBM/


This is starting to get really, really serious.
I was over at Harvard yesterday, playing Chess. It's turning into a Skeleton Crew over there.

A good portion of the people walking the streets there, are wearing masks.

[reload141]

Read on Twitter

Lacob really once was a minority owner of the Celtics and is from Framingham. What a dick

Imagine having a brand new arena and Steph/Klay out for majority of the year.....then coronavirus takes hold.... they might be struggling to pay that off.

Oh wait, I forgot they are "LiGhT yEaRs AhEaD"

[threrf23]

from WebMD:

The CDC recommends the antiviral drugs baloxavir marboxil (Xofluza), oseltamivir (Tamiflu), and zanamivir (Relenza) for both flu prevention and treatment

I imagine the same would apply to the Coronavirus.

And I tend to suspect that easy, prescription free, and ideally affordable access to these drugs might do more good than quarantines.

Am I ignorant?

[Fencer reregistered]

I was over at Harvard yesterday, playing Chess.

Where does one play chess at Harvard these days?

Back in the day, it was the main floor of the Science Center. We also used to play in my department. Indeed, one of the two highest-rated players I got clobbered by was Ken Regan when he was visiting graduate schools. (The other was Kim Commons, who I went to undergrad with. But I beat him once at Double Bughouse w/ Diane Saeveride as my partner.)

[Parliament10]

I was over at Harvard yesterday, playing Chess.

Where does one play chess at Harvard these days?

Back in the day, it was the main floor of the Science Center. We also used to play in my department. Indeed, one of the two highest-rated players I got clobbered by was Ken Regan when he was visiting graduate schools. (The other was Kim Commons, who I went to undergrad with. But I beat him once at Double Bughouse w/ Diane Saeveride as my partner.)

We play at the "New" Smith Student Center. Took them 2.5 years to Renovate it.
Chess Table inside and outside. We have Tournaments there, too.

[Ed Pinkney]

from WebMD:

The CDC recommends the antiviral drugs baloxavir marboxil (Xofluza), oseltamivir (Tamiflu), and zanamivir (Relenza) for both flu prevention and treatment

I imagine the same would apply to the Coronavirus.

And I tend to suspect that easy, prescription free, and ideally affordable access to these drugs might do more good than quarantines.

Am I ignorant?

I don't know the specifics for corona, but in general anti-viral medications are limited in what viruses they can be used for as well as their overall effectiveness. This is why viral pathogen based pandemics are always going to be a risk of occurring, especially when transmission is difficult to control (like a respiratory based one).

[exculpatory]

from WebMD:

The CDC recommends the antiviral drugs baloxavir marboxil (Xofluza), oseltamivir (Tamiflu), and zanamivir (Relenza) for both flu prevention and treatment

I imagine the same would apply to the Coronavirus. NOT AT ALL.

And I tend to suspect that easy, prescription free, and ideally affordable access to these drugs might do more good than quarantines.

Am I ignorant?

There is NO data I am aware of ATM clearly demonstrating that COVID 19 responds to any of the THREE anti-influenza antivirals in your post. I would be VERY interested in seeing any data whatsoever on this. (This is NOT a matter of 1 size fits all - just because Tamiflu, Xofluza, & Relenza are efficacious VS influenza does NOT AT ALL mean they are efficacious VS COVID 19.)

I AM aware of impending & ongoing studies involving REMDESIVIR. See below.

Gilead Sciences
Approach: Treatment
Stage: Phase 3

“Gilead’s remdesivir, an intravenous treatment, has already been used to treat one infected patient in the U.S. and will soon be deployed in a pair of large, late-stage studies in Asia. Later this month, Gilead will recruit about 1,000 patients diagnosed with the coronavirus to determine whether multiple doses of remdesivir can reverse the infection. The primary goals are reducing fever and helping patients get out of the hospital within two weeks. The drug, which previously failed in a study on Ebola virus, is also being studied in smaller trials in China and the U.S.”

[threrf23]

There is NO data I am aware of ATM clearly demonstrating that COVID 19 responds to any of the THREE anti-influenza antivirals in your post. I would be VERY interested in seeing any data whatsoever on this. (This is NOT a matter of 1 size fits all - just because Tamiflu, Xofluza, & Relenza are efficacious VS influenza does NOT AT ALL mean they are efficacious VS COVID 19.)

I AM aware of impending & ongoing studies involving REMDESIVIR. See below.

Gilead Sciences
Approach: Treatment
Stage: Phase 3

“Gilead’s remdesivir, an intravenous treatment, has already been used to treat one infected patient in the U.S. and will soon be deployed in a pair of large, late-stage studies in Asia. Later this month, Gilead will recruit about 1,000 patients diagnosed with the coronavirus to determine whether multiple doses of remdesivir can reverse the infection. The primary goals are reducing fever and helping patients get out of the hospital within two weeks. The drug, which previously failed in a study on Ebola virus, is also being studied in smaller trials in China and the U.S.”

But doctors have been treating patients for more than a month, with medication, and there must be some indication of what will and will not work.

And I mean, even if they won't necessarily help, are the side effects of common anti-virals too severe to risk use?

[exculpatory]

There is NO data I am aware of ATM clearly demonstrating that COVID 19 responds to any of the THREE anti-influenza antivirals in your post. I would be VERY interested in seeing any data whatsoever on this. (This is NOT a matter of 1 size fits all - just because Tamiflu, Xofluza, & Relenza are efficacious VS influenza does NOT AT ALL mean they are efficacious VS COVID 19.)

I AM aware of impending & ongoing studies involving REMDESIVIR. See below.

Gilead Sciences
Approach: Treatment
Stage: Phase 3

“Gilead’s remdesivir, an intravenous treatment, has already been used to treat one infected patient in the U.S. and will soon be deployed in a pair of large, late-stage studies in Asia. Later this month, Gilead will recruit about 1,000 patients diagnosed with the coronavirus to determine whether multiple doses of remdesivir can reverse the infection. The primary goals are reducing fever and helping patients get out of the hospital within two weeks. The drug, which previously failed in a study on Ebola virus, is also being studied in smaller trials in China and the U.S.”

But doctors have been treating patients for more than a month, with medication, and there must be some indication of what will and will not work. SEE BELOW.

And I mean, even if they won't necessarily help, are the side effects of common anti-virals too severe to risk use? NO

Excellent excellent question!
I simply do not know what has been tried & what anecdotally ‘may’ have appeared to be beneficial. In the absence of a clinically proven anti-viral efficacious for CORVID 19, I would be very surprised if these anti-influenza anti-virals have not been administered to a few VERY ill CORVID 19 patients.

PS Understand that carefully designed & adequately powered, randomized, double blind, prospective Phase 3 clinical trials are required by the FDA to prove that a drug has appropriate efficacy & an acceptable safety profile. Random off the cuff use of 1 of these 3 drugs in a VERY ill CORVID 19 patient is reasonable in the absence of an approved anti-viral therapy, but proves nothing.

[jfs1000d]

There is NO data I am aware of ATM clearly demonstrating that COVID 19 responds to any of the THREE anti-influenza antivirals in your post. I would be VERY interested in seeing any data whatsoever on this. (This is NOT a matter of 1 size fits all - just because Tamiflu, Xofluza, & Relenza are efficacious VS influenza does NOT AT ALL mean they are efficacious VS COVID 19.)

I AM aware of impending & ongoing studies involving REMDESIVIR. See below.

Gilead Sciences
Approach: Treatment
Stage: Phase 3

“Gilead’s remdesivir, an intravenous treatment, has already been used to treat one infected patient in the U.S. and will soon be deployed in a pair of large, late-stage studies in Asia. Later this month, Gilead will recruit about 1,000 patients diagnosed with the coronavirus to determine whether multiple doses of remdesivir can reverse the infection. The primary goals are reducing fever and helping patients get out of the hospital within two weeks. The drug, which previously failed in a study on Ebola virus, is also being studied in smaller trials in China and the U.S.”

But doctors have been treating patients for more than a month, with medication, and there must be some indication of what will and will not work.

And I mean, even if they won't necessarily help, are the side effects of common anti-virals too severe to risk use?

Having had my father go through late stage cancer treatment, sometimes doctors don’t have an answer and throw **** again the wall.

They will say, we can try this because it worked in a closely related case. They don’t like to just not try anything.

I am annoyed at all the people thinking this is overblown. It isn’t. This is a serious matter. Not sure it is time to panic, but can people stop trying to stick their head in the sand.


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