Semi-OT: Coronavirus (COVID-19) Discussion Thread VI (Don't Read Post 1 & FAQ)

[OkcSinceSGA]

For the anti Hydroxychloroquine+Zpak, someone posted good data. The risk of QT interval is EXTREMELY overstated. I'm shocked like he is that at such a low occurance the FDA makes them blast prolonged QT interval warnings on these drugs.

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That guy is compromised

Hahaha. Is the data legit from what you can tell? Or wouldn't trust it?

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[Zenzibar]

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[DingleJerry]

Shocking for a governor to say that, ether lying or admitting to gross incompetence. Either way, it's bad.

But just wanted to say that in my talks with people 2-3 weeks ago prior to lockdown almost every person I talked to did not know about the asymptomatic spread. And didn't know how combining that with not having a vaccine makes it way worse than the normal flu. They also didn't get how that made this different than previous scares like Swine/SARS, etc. The question as to why they didn't know is incompetent leaders and their schills were pumping "it's just the flu" all over the place and people just soak up what they want to believe. After that, it's just people refusing to look into things on their own and learn. I have a joke/saying I often use saying something like 50% of the population is just completely stupid. Mostly its just a joke, but really its not that far off.

Also, I know young people have been ripped for how dumb they were going to spring break. Well, literally every single old person (no hyperbole) I talked to in the lead up to this repeated the "it's just the flu, it's the media scaring us, we're not scared and gonna keep on doing what we do" take I just mentioned. I think we can all guess where their info was coming from.

The possibly dumbest or ironic part of the Trump admins response is that it was all about trying to protect the economy. That's really why he was so rosy about everything. Who knows, maybe it was just to keep it propped up for a few more weeks while his buddies dumped stock or shorted the market, idk. But, the reality is the best thing for the economy would've been that since we were among the last to get this due to the isolation if we would have seen it coming and gotten way ahead of this so as to not have it blow up then we'd be the only functioning economy in the world right now and be at a huge advantage. Short term mindset won out.

[chrismikayla]

I don't mean to possibly derail the thread. But I can almost see how many people would think this was a conspiracy and was intentional. It's hard to believe some government officials and organizations can be this incompetent by accident.

[Jordan-esque]

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[Neutral 123]

I don't mean to possibly derail the thread. But I can almost see how many people would think this was a conspiracy and was intentional. It's hard to believe some government officials and organizations can be this incompetent by accident.

You couldn't keep a job sweeping a floor to be that incompetent. No way I'll believe that this was incompetence from the so called best and brightest. What these people absolutely lack isn't education, isn't intelligence, it's a sense of morality.

[zimpy27]

For the anti Hydroxychloroquine+Zpak, someone posted good data. The risk of QT interval is EXTREMELY overstated. I'm shocked like he is that at such a low occurance the FDA makes them blast prolonged QT interval warnings on these drugs.

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That guy is compromised

Hahaha. Is the data legit from what you can tell? Or wouldn't trust it?

Sent from my LM-Q710(FGN) using RealGM mobile app

The exact numbers may not be that. But yes, chloroquine causes very few problems unless used chronically, people with lupus take it every day for years and it can cause issues with their eyes. There will always be a few cases of people that get attributed to dying because of a drug. It would be as mild as panadol, aspirin, ibuprofen.

You still have to be careful though, as you do with all drugs, chloroquine does have a number of interactions with other drugs that will dramatically increase the rate of QT interval problems.

My main fear with this drug is that if it gets mass usage then we may effectively make it useless by trapping down the virus to a mutant that is immune to the drugs mode of action. If we do that before the virus infects everyone then the rest of the population might be screwed. Especially if it gives us a false sense of security.

[KingDavid]

For the anti Hydroxychloroquine+Zpak, someone posted good data. The risk of QT interval is EXTREMELY overstated. I'm shocked like he is that at such a low occurance the FDA makes them blast prolonged QT interval warnings on these drugs.

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How many of those drugs are given to people with preexisting heart disease?

[Dirk]

That guy is compromised

Hahaha. Is the data legit from what you can tell? Or wouldn't trust it?

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The exact numbers may not be that. But yes, chloroquine causes very few problems unless used chronically, people with lupus take it every day for years and it can cause issues with their eyes. There will always be a few cases of people that get attributed to dying because of a drug. It would be as mild as panadol, aspirin, ibuprofen.

You still have to be careful though, as you do with all drugs, chloroquine does have a number of interactions with other drugs that will dramatically increase the rate of QT interval problems.

My main fear with this drug is that if it gets mass usage then we may effectively make it useless by trapping down the virus to a mutant that is immune to the drugs mode of action. If we do that before the virus infects everyone then the rest of the population might be screwed. Especially if it gives us a false sense of security.

Hydroxychloroquine, the malaria medicine that some doctors have been trying as a treatment against Covid-19, hasn’t shown encouraging results so far at France’s Pitie Salpetriere hospital.

“We’ve used it a fair bit because it was one of the hopes,” Eric Caumes, head of infectious diseases at the Paris hospital, said on BFM TV. “But we don’t have the impression that there’s spectacular efficacy. It’s even probably not effective.” Caumes said he would have more formal data around the end of the week.

Pitie Salpetriere was rated France’s best hospital in a 2020 Newsweek ranking.

https://www.bloomberg.com/news/articles/2020-04-02/hyped-malaria-drug-not-showing-much-effect-at-one-paris-hospital

[madmaxmedia]

I am pretty sure no one is 'anti Hydroxychloroquine+Zpak', but there are a lot of people who are very skeptical of the French doctor and his studies.

What seems very suspect to me about that doctor is that he's going around pronouncing that this is the cure to COVID-19 based on extremely unsubstantial data. It's one thing to wave your arms and shout, "Hey I think I found something everyone come take a look!" and discuss your findings with other scientists and professionals who can help move things forward ASAP. But that's not what he's doing, and that seems odd to me.

Everyone wants to see fast action on at least some basic testing that can actually give us data on its effectiveness, before a mad rush for the medicine (which has already happened.) I don't think it's wrong at this point for doctors to prescribe it in emergency cases, but they way its being talked about in the news and media is pretty irresponsible. We ignored the science earlier this year, and it didn't work out too well.

[madmaxmedia]

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[Zenzibar]

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[homecourtloss]

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What the hell is that sign saying?

[chrismikayla]

Here is an interesting article about viral load and people having severe vs mild symptoms. It speaks about being around sick patients for a long time and face to face with someone more than a few seconds unprotected increased your risk of severe illness.


https://www.nytimes.com/2020/04/01/opinion/coronavirus-viral-dose.html?action=click&module=Opinion&pgtype=Homepage

[madmaxmedia]

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What the hell is that sign saying?

"How often did he save everyone on Gilligan's Island?"

[Optimus_Steel]

Jobless claims soar to record-breaking 6.648 million

The U.S. Labor Department released fresh data on Thursday morning that showed the effect of the novel coronavirus on employment in the U.S. The number of Americans filing for unemployment benefits spiked to a record-breaking 6.648 million for the week ending March 28. Consensus expectations were for 3.76 million claims. The prior week’s figure was revised higher to 3.307 million claims from 3.283 million. Prior to the week ending March 21, the previous record was 695,000 claims filed the week ended October 2, 1982.

“The deterioration of the labor market in the past two weeks almost defies belief,” Nick Bunker, Indeed Hiring Lab's director of economic research, wrote in an email Thursday. “Since March 14, approximately 3.8% of the working age population has filed for unemployment. For context, during the Great Recession, the share of the population dropped 4.6 percentage points from December 2007 to December 2009. That took two years. The labor market is in a historic freefall."

https://finance.yahoo.com/news/coronavirus-covid-weekly-initial-jobless-claims-march-28-165758189.html

This is just the beginning on unemployment filings. In upsets me that congress passed legislation that comes nowhere near close to help everyday Americans with this, as we all healthcare coverage.

Well, Healthcare is a separate issue, but unemployment wise they did in fact go above and beyond with the proposal of the $600 a week on top of one's unemployment benefits (and vastly extending who qualifies for these benefits) for up to 4 months. I was incredibly surprised this much money was flat allocated. It is a major pay raise for a huge chunk of Americans who were laid off. Now we will see how seamlessly it is distributed, as that is a whole other matter (granted, to their credit, this is the reason why a flat amount was proposed).

Healthcare is not a separate issue because large proportions of the country have health insurance coverage thru their employers, they are let go they lose they paycheck and the healthcare coverage.

The employment issue they decided on still leaves tons of people unable to get unemployment benefits due to being self employed, or gig workers, etc. Also the unemployment is based on a state by state basis, and every state has different ways to apply, different payouts, etc. Here in Florida for example the website for unemployment has been outdated and not working right for years and out of spite our politicians refused to fix it. Now thousands are trying to get thru on the website and apply but they cant, it just crashes over and over. Reality is that unemployment numbers are likely far below what they are reporting because people are having trouble just applying for unemployment. Seems like regular people have to jump thru hoops just to do an application, while large corporations have an easy and short application process for help.

Also nothing has been done at all to freeze mortgage, rent, utilities, student loan, car, credit card payments, etc., except for some instances here and there. Bills are still coming and funds from the government seem a ways from arriving.

Also, in the last 2 weeks more people have lost their jobs than the first 6 months of the Great Depression, meanwhile Congress left Washington for 3+ weeks.

[homecourtloss]

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What the hell is that sign saying?

"How often did he save everyone on Gilligan's Island?"

I read “how of ten.”

IQ dropping, getting fat as **** here at home.

[Wilfried]

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Gold

[zimpy27]

Hahaha. Is the data legit from what you can tell? Or wouldn't trust it?

Sent from my LM-Q710(FGN) using RealGM mobile app

The exact numbers may not be that. But yes, chloroquine causes very few problems unless used chronically, people with lupus take it every day for years and it can cause issues with their eyes. There will always be a few cases of people that get attributed to dying because of a drug. It would be as mild as panadol, aspirin, ibuprofen.

You still have to be careful though, as you do with all drugs, chloroquine does have a number of interactions with other drugs that will dramatically increase the rate of QT interval problems.

My main fear with this drug is that if it gets mass usage then we may effectively make it useless by trapping down the virus to a mutant that is immune to the drugs mode of action. If we do that before the virus infects everyone then the rest of the population might be screwed. Especially if it gives us a false sense of security.

Hydroxychloroquine, the malaria medicine that some doctors have been trying as a treatment against Covid-19, hasn’t shown encouraging results so far at France’s Pitie Salpetriere hospital.

“We’ve used it a fair bit because it was one of the hopes,” Eric Caumes, head of infectious diseases at the Paris hospital, said on BFM TV. “But we don’t have the impression that there’s spectacular efficacy. It’s even probably not effective.” Caumes said he would have more formal data around the end of the week.

Pitie Salpetriere was rated France’s best hospital in a 2020 Newsweek ranking.

https://www.bloomberg.com/news/articles/2020-04-02/hyped-malaria-drug-not-showing-much-effect-at-one-paris-hospital

I'll be looking forward to see the studies but there are so many variables to consider.

The drug slows the virus replicating, it doesn't stop the cytokine storm or the excessive immune reaction of the body that has already been triggered (leading patients to go to the hospital). If you use it in a hospital setting it's merely stopping the virus, it's not undoing damage or reducing damage or even stopping the exaggerated immune response of the body. I hope that hasn't been lost in translation somewhere but I'll read up on the trials that failed.

Trial participants should be mild with the outcome measure being the virus titer.

[chrismikayla]

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Ha she cut that interview off real quick LOL. It's like she was listening to someone in her earpiece saying to hurry up and get him off the air. But he is spot on though.