Post#1944 » by exculpatory » Sat Sep 4, 2021 12:52 am
Excellent work!
Will be all over the news!
Worth a quick read.
Ex
STUDY SUMMARY
The Impact of Mask Distribution and Promotion on Mask Uptake and COVID-19 in Bangladesh
A growing body of scientific evidence suggests that face masks can protect against COVID-19. There is, however, limited rigorous evidence on the extent to which mask- wearing is effective in reducing COVID-19 in a real-life situation with imperfect and inconsistent mask use. In Bangladesh, researchers and IPA partnered with Bangladeshi policymakers and a local NGO to design and evaluate various strategies to increase mask-wearing and assess the impact of community mask-wearing on SARS-CoV-2 infection rates. They found that a four-part intervention (the “NORM model”) tripled mask usage (a 29- percentage-point increase), and increased physical distancing by 5 percentage points. Further, this increase in mask-wearing reduced symptomatic SARS- CoV-2 infections. When surgical masks were employed, 1 in 3 symptomatic infections were avoided for individuals 60+ years old, the age group that faces the highest risk of death following infection.
This was the first large-scale randomized evaluation to demonstrate the effectiveness of masks in a real-world
setting.
Policy Issue
As of August 2021, the COVID-19 pandemic has taken the lives of more than 4.4 million people.[1] While vaccines may contain the spread of SARS-CoV-2 in the long-term, it is unlikely that a substantial fraction of the population in low- and middle-income countries will have access to vaccines by the end of 2021. Determining scalable and effective means of combating COVID-19 is thus of first-order policy importance. Currently, institutions such as the World Health Organization (WHO) recommend masks as part of an overall portfolio of protective behaviors against COVID-19. Yet conversations with scientific advisors and institutions such as WHO and the U.K. government indicated that high-quality evidence on the effectiveness of mask-wearing would likely influence policy decisions about mask use.
Prior evidence to comprehensively answer policy-makers’ questions is limited. First, while laboratory evidence shows that masks can reduce exhaled viral load and thus the probability of transmitting the virus,[2] the extent to which this effect manifests at a community level in the real world, where masks may be worn imperfectly and inconsistently, is uncertain. Second, there is limited evidence on effective ways to
rapidly promote mask usage in community settings. Third, critics argue that such adoption may lead to compensatory risky behaviors such as reducing physical distancing.
This research aimed to fill these gaps with the first large-scale cluster- randomized evaluation of the impact of masks to reduce COVID-19. The dual goals of the randomized evaluation were (a) to identify strategies to encourage community-wide mask-wearing and (b) to track changes in symptomatic SARS CoV-2 infections as a result of the intervention.
Evaluation Context
Bangladesh, the eighth most populous country in the world (165 million people), had approximately 1.5 million reported COVID-19 cases as of August 2021.[3] It is also one of the most densely populated countries (density of 2,890 people/mi2),[4] making preventive measures such as physical distancing extremely difficult to implement in many situations. In Bangladesh, the government strongly recommended mask use from early April 2020 and formally mandated mask use in late May 2020, threatening to fine those who did not comply.
Despite this, IPA and local partners documented low mask-wearing: in a wave of surveillance between May 21-25, 2020, around 51 percent of more than 152,000 individuals observed were wearing a mask. This percentage declined rapidly: in a second wave of surveillance in June 2020, observed mask- wearing had dropped to 26 percent with 20 percent wearing masks that covered their mouth and nose.
Details of the Intervention
Researchers partnered with the Ministry of Health and Family Welfare, the Bangladesh Medical Research Council, a2i (a data-focused arm of the government), Green Voice (a local NGO), and North South University to evaluate the effectiveness of various strategies on increasing mask-wearing and assess the impact of community mask wearing on rates of COVID-19.
To select participating villages, the research team chose 1,000 rural and peri-urban villages based on population data and in-person scoping. They used a pair-wise randomization to select 300 intervention and 300 comparison villages within the same upazila (Bangladesh is divided into 492 upazilas). Paired villages were similar in terms of (limited) COVID-19 case data, population size, and population density. All villages are at least 2 km apart to minimize spillover risk. Comparison villages continued mask- wearing as usual.
The intervention was designed to last 8 weeks in each village. The intervention started in different villages at different times, rolling out over a 6-week period from November 2020 to January 2021. A core set of interventions was implemented in all treatment villages. Additionally, incentives and behavioral nudges were tested in subsets of treatment villages to evaluate whether they had any additional impact on mask-wearing.
Mask Distribution and Promotion (now called the NORM model).
The intervention (implemented in all 300 intervention villages) comprises four main elements:
No-cost free masks distribution One-third of the intervention villages received a cloth mask and two-thirds of the intervention villages received a surgical mask[5] during household distribution and distribution at marketplaces and other public locations weekly or every fortnight. Masks were also distributed at mosques on three Fridays during the first four weeks of the intervention. Offering information on mask-wearing Along with the distribution, the research team showed a brief video of notable public figures discussing why, how, and when to wear a mask. The video featured the Honorable Prime Minister of Bangladesh Sheikh Hasina, the head of the national Imam Training Academy, and the national cricket star Shakib Al Hasan. During the distribution visit, households also received a brochure based on WHO materials depicting proper mask wearing.
Reinforcement in-person and in public In an effort to create a social norm, mask promoters encouraged non-mask wearers to wear a mask, providing a mask if the individual did not have one. Mask promoters also played public service announcements in public areas using handheld microphones.
Modeling and endorsement by trusted leaders. Religious leaders (imams) discussed the importance of mask-wearing at Friday prayers from a scripted speech provided by the research team.
Incentives and Behavioral Nudges
To test whether strategies other than the NORM model had an additional impact on mask usage, households in intervention villages also received different types of encouragement. The research team randomly selected villages in the intervention group (total 300 villages) to receive the following components:
Incentives: Villages were randomized to receive no incentive, a monetary incentive (USD 190 per village given to the village leader for a project benefiting the public), or a non-monetary incentive (certificate of recognition from the Government of Bangladesh) if village-level mask wearing among adults exceeded 75 percent eight weeks after the start of the intervention.
Public commitment (signage): To encourage the formation of social norms through public signaling, households in half of the villages were asked to display a sign that they were mask- wearing households.
Text reminders: Households were randomized to receive either twice-weekly text message reminders about the importance of mask-wearing or no text reminders.
Message framing (altruistic vs. self-protection): Households were randomized to have the intervention messages framed either altruistic or providing self-protection.
Network effects: In villages with signage, two-thirds of the households received zero, 50, or 100 percent weekly text messages.
Verbal commitment: In villages without signage, two-thirds of the households were randomly asked to make a verbal commitment to be a mask-wearing household or not.
Results and Policy Lessons
Overall, the core intervention induced 29 out of every 100 people to wear masks, increased physical distancing and reduced the number of people with symptomatic SARS-CoV-2 infections by 9 percent. Surgical masks were especially effective in reducing symptomatic SARS-CoV-2 infections and reduced symptomatic infections in people 60+ by 35 percent.
In villages that received the intervention, mask use increased by 29 percentage points (from 13 percent in the comparison villages to 42 percent in treatment villages). Mask use increased most in mosques (37 percentage points). A pilot and our scale-up activities suggest that in-person public reinforcement is a critical part of the intervention.
The intervention also increased physical distancing in villages that received the intervention, contrary to concerns that mask-wearing would provide a false sense of security and promote risky behaviors like failing to maintain appropriate physical distance from others. On average, physical distancing increased by 5 percentage points across all locations in intervention villages, but the change was larger in some locations than others. In markets, people were substantially more likely to physically distance (7 percentage points increase). In mosques, researchers observed no change.
The intervention reduced COVID-19 (symptomatic SARS-CoV-2 infections) and COVID-like symptoms. Free mask distribution and promotion reduced the proportion of people who reported COVID-like symptoms on average by 11 percent, which was driven mainly by the effects of surgical masks. Villages where cloth masks were distributed experienced a 5 percent reduction in symptoms, while villages where surgical masks were distributed saw a reduction of 12 percent. About a third (40 percent) of those who reported COVID-19 symptoms agreed to have their blood tested for SARS-CoV-2. On average, researchers found a decrease of symptomatic SARS-CoV-2 infections of 9 percent. This reduction was higher in villages that wore a surgical mask (11 percent) and in these, among individuals aged 60+ (35 percent).
None of the behavioral nudges or incentives at the community- or household-level led to additional increases in mask-wearing or physical distancing. Neither text message reminders, public signage, monetary and non-monetary incentives, altruistic messaging, nor verbal commitments had any effect on mask-wearing above and beyond the core intervention. Mask color had a statistically significant but minor impact on mask adoption.
This study has several implications for policy-makers. First, there is clear evidence that community mask-wearing can reduce COVID-19. The effects were substantially larger in communities where surgical masks were distributed, consistent with greater filtration efficiency measured in laboratories, and surgical masks reduced 1 in 3 symptomatic infections among individuals aged 60+.
Second, community mask-wearing can be increased through a combination of four core intervention elements, now called the “NORM” model, which stands for “No-cost mask distribution, Offering information, Reinforcement to wear masks, and Modeling by local leaders. Many other factors did not increase mask-wearing: researchers found no evidence that public commitments, village level incentives, text messages, altruistic messaging, or verbal commitments changed mask-wearing behavior in this context, which underscores the importance of rigorous, real-world testing before rolling out behavioral interventions at scale.
Whether people with respiratory symptoms should generally wear masks to prevent respiratory virus transmission –– including for viruses other than SARS Co-V-2 –– is an important area for future research. The findings from this study suggest that such a policy may benefit public health.
Outcome Measures & Protocol
Before the intervention began, the research team obtained informed consent and collected data and blood samples following appropriate and approved public health protocols. All protocols were approved by the Bangladesh Medical Research Council, IPA, and Yale University.
The research team directly observed mask-wearing and physical distancing in public locations, including mosques, markets, main entrance roads to villages, and tea stalls, for 10 weeks: during the intervention at selected intervals and two weeks after all intervention activities had ended. The research team also conducted longer-term data on mask wearing behavior 20-27 weeks after the launch of the interventions. Correct mask-wearing was defined as wearing either a project mask or an alternative mask over both the mouth and nose. A person was recorded as practicing physical distancing if they were at least one arm’s length away from all other people. Surveillance staff were separate from mask promoters and wore no identifying apparel while passively observing mask- wearing and physical distancing behaviors.
The investigators conducted a survey five and nine weeks after the start of the intervention to understand if participants had symptoms consistent with COVID-19 in the previous week and over the previous month. Twelve weeks after the start of the intervention, blood samples were collected and tested from participants who provided samples at baseline as well as from participants who reported COVID-like symptoms at any point in the evaluation. The blood samples were tested for SARS-CoV-2 antibodies to determine whether the participants had evidence of prior infection.
The research team gratefully acknowledges GiveWell, which recommended a grant from the Effective Altruism Global Health and Development Fund to support this research.
Sources
[1] Johns Hopkins University (JHU) “COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE)”
[2] Leung, N.H.L., Chu, D.K.W., Shiu, E.Y.C. et al. “Respiratory virus shedding in exhaled breath and efficacy of face masks”.
[3] Johns Hopkins University (JHU) “COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE)”
[4] World Population Review, 2020. “Countries by Density 2020”
[5] The materials used to make surgical masks have a higher filtration efficiency than the types of cloth
typically used to make cloth masks, but cloth masks can be sewn without specialized equipment and can have less leakage because they fit the face more closely. Filtration efficiency of the project’s high- quality surgical masks was tested before and after washing. They were found to have high filtration efficiency even after washing, so when they were distributed, recipients were told that they should wash and reuse all project masks (even the surgical ones).
RESEARCHERS
Jason Abaluck, Laura H. Kwong, Ashley Styczynski, Ashraful Haque, Md Alamgir Kabir, Ellen Bates-Jefferys, Emily Crawford, Jade Benjamin-Chung, Salim Benhachmi, Shabib Raihan, Shadman Rahman, Peter Winch, Stephen Luby, Mushfiq Mobarak
COUNTRY
Bangladesh
PARTNERS
Aspire to Innovate (a2i), Institute of Epidemiology, Disease Control and Research (IEDCR), Ministry of Health and Family Welfare, Bangladesh, Yale Research Initiative on Innovation and Scale (Y-RISE), Stanford University Medical School, Tata Institute of Fundamental Research, Green Voice, North South University
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