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Wizards Board COVID-19 Thread

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Re: Wizards Board COVID-19 Thread 

Post#361 » by dckingsfan » Wed Sep 29, 2021 5:30 pm

nate33 wrote:
dckingsfan wrote:The point of my response was:
1) researchers are advocating research in this area because they think it is the right way to go AND they want to get funded
2) we don't know how fast natural immunity wanes in the nasal cavity, we think quite fast
3) we "may" need to do both a nasal vaccine and a intermuscular vaccine
4) we don't know how often a nasal vaccine would need to be applied (how does this work in a worldwide scenario)

The third point is the one I am interested in... will the anti-vaxxers be good with ANY vaccine.

I'm only bringing it up because of Bradley Beal.

My point is that Beal, with natural immunity (developed just 2 months ago) is almost certainly as safe, if not safer than his vaccinated teammates. And furthermore, the best research we have suggests that he is even less likely to be an asymptomatic spreader of Covid thanks to his mucosal antibodies.

There is absolutely no scientific rationale to treat Beal differently than his vaccinated teammates. If anything, he is even less of a danger to himself and others than at least 90% of the people on the planet. If anyone can safety go maskless, it's Beal.

Now, perhaps that all changes in 10 months. Maybe natural immunity does wane. But recent natural immunity is as strong as anything else out there, and studies are also showing that it doesn't fade as quickly as vaccination. (FWIW, SARS-COV-1 natural immunity has lasted 15 years.)

Sorry, didn't understand the context. And I think at this point - even when I agree with a point it is going to seem off-base.

So, to be clear. I agree that Beal is certainly as safe as his teammates. And he is no more at risk of spreading Covid than his teammates as well.

Separate point. Do I think that Beal should get vaccinated. Yes. When is the key. I would say at around the six month time frame it would be optimal. Do we have a process for that - no.
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Re: Wizards Board COVID-19 Thread 

Post#362 » by Kanyewest » Wed Sep 29, 2021 8:24 pm

So far guys like Lamar Jackson and Michael Porter Jr. have gotten it twice. The bigger issue is that they may give it to someone else.
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Re: Wizards Board COVID-19 Thread 

Post#363 » by Dat2U » Wed Sep 29, 2021 8:27 pm

Kanyewest wrote:So far guys like Lamar Jackson and Michael Porter Jr. have gotten it twice. The bigger issue is that they may give it to someone else.


The issue is that anyone can give it to anyone regardless of vax status.
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Re: Wizards Board COVID-19 Thread 

Post#364 » by Dat2U » Wed Sep 29, 2021 8:30 pm

Kanyewest wrote:
Dat2U wrote:Novavax. Someone tell me why that is not approved yet?


But the challenges facing Novavax do not stem from how well the vaccine appears to work. Rather, Novavax has struggled to find a way to produce its shots. (Novavax did not respond to Fortune's request to comment.)

Novavax says it is currently producing COVID-19 vaccines at 20 plants globally and will have the capacity to make 2 billion vaccines in 2022, but none of the firm's vaccines are currently being used beyond clinical trials.

In the U.S., Novavax has yet to apply to the Food and Drug Administration (FDA) for emergency use authorization and says it may not apply for approval until the fourth quarter of this year after months of delays.

U.S. regulators told the New York Times in August that the hold-up stemmed from poor quality control at Novavax's manufacturing facilities. Novavax later said a contract it signed with the U.S. government has constrained its ability to produce doses. Since July 2020, Novavax has received $1.75 billion from former President Donald Trump’s Operation Warp Speed to develop and manufacture its vaccines. As part of the deal, Novavax says that it was directed to work with manufacturers including the Japanese-owned and U.S.-headquartered pharmaceutical manufacturer Fujifilm Diosynth Biotechnologies, which has slowed production.


https://fortune.com/2021/09/24/novavax-who-approval-covid-vaccine-mrna-covax/


It's a shame. I think they are the best alternative to those concerned about the MRNA options. Far better than J&J.
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Re: Wizards Board COVID-19 Thread 

Post#365 » by Ruzious » Wed Sep 29, 2021 8:46 pm

Dat2U wrote:
Kanyewest wrote:
Dat2U wrote:Novavax. Someone tell me why that is not approved yet?


But the challenges facing Novavax do not stem from how well the vaccine appears to work. Rather, Novavax has struggled to find a way to produce its shots. (Novavax did not respond to Fortune's request to comment.)

Novavax says it is currently producing COVID-19 vaccines at 20 plants globally and will have the capacity to make 2 billion vaccines in 2022, but none of the firm's vaccines are currently being used beyond clinical trials.

In the U.S., Novavax has yet to apply to the Food and Drug Administration (FDA) for emergency use authorization and says it may not apply for approval until the fourth quarter of this year after months of delays.

U.S. regulators told the New York Times in August that the hold-up stemmed from poor quality control at Novavax's manufacturing facilities. Novavax later said a contract it signed with the U.S. government has constrained its ability to produce doses. Since July 2020, Novavax has received $1.75 billion from former President Donald Trump’s Operation Warp Speed to develop and manufacture its vaccines. As part of the deal, Novavax says that it was directed to work with manufacturers including the Japanese-owned and U.S.-headquartered pharmaceutical manufacturer Fujifilm Diosynth Biotechnologies, which has slowed production.


https://fortune.com/2021/09/24/novavax-who-approval-covid-vaccine-mrna-covax/


It's a shame. I think they are the best alternative to those concerned about the MRNA options. Far better than J&J.

It's a shame for people who invested in their stock.
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Re: Wizards Board COVID-19 Thread 

Post#366 » by Kanyewest » Wed Sep 29, 2021 8:56 pm

Dat2U wrote:
Kanyewest wrote:So far guys like Lamar Jackson and Michael Porter Jr. have gotten it twice. The bigger issue is that they may give it to someone else.


The issue is that anyone can give it to anyone regardless of vax status.


The transmission of the Covid is lower though if you are vaccinated.

One massive analysis of Delta transmission comes from the UK REACT-1 programme, led by a team at Imperial College London, which tests more than 100,000 UK volunteers every few weeks. The team ran Ct analyses for samples received in May, June and July, when Delta was rapidly replacing other variants to become the dominant driver of COVID-19 in the country. The results suggested that among people testing positive, those who had been vaccinated had a lower viral load on average than did unvaccinated people. Paul Elliott, an epidemiologist at Imperial, says that these results differ from other Ct studies because this study sampled the population at random and included people who tested positive without showing symptoms.


https://www.nature.com/articles/d41586-021-02187-1
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Re: Wizards Board COVID-19 Thread 

Post#367 » by Kanyewest » Wed Sep 29, 2021 10:01 pm

People who have natural immunity and aren’t vaccinated are twice as likely to contract COVID as those who’ve been vaccinated (Pre-Delta)

https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.htm
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Re: Wizards Board COVID-19 Thread 

Post#368 » by Kanyewest » Wed Sep 29, 2021 10:09 pm

I live in the Washington DC area. The District and its suburbs are solidly blue, but the hospitals here are almost full. The major childrens hospital, Children's National, is so full that they're sending families to Philadelphia for routine procedures.

Why? Because our hospitals are taking record numbers of transfer patients from the red, rural parts of Virginia and Maryland and from other states hundreds of miles away.

The vaccination rate where I live is high, and the positive test rate here is under 5%, but the medical system is still under heavy strain because we're helping patients from other places.
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Re: Wizards Board COVID-19 Thread 

Post#369 » by nate33 » Wed Sep 29, 2021 10:17 pm

Kanyewest wrote:People who have natural immunity and aren’t vaccinated are twice as likely to contract COVID as those who’ve been vaccinated (Pre-Delta)

https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.htm

So what?

A jogger wearing a helmet is less likely to fall and crack his skull than a jogger without a helmet, but that doesn't mean we should mandate helmets on all joggers. The point is, a jogger is at very low risk of cracking his skull with or without the helmet. Just like a naturally immune person has a very low risk of being reinfected with a serious case of Covid with or without the vaccine.

Also, that Kentucky study has a miniscule sample size. Other studies with bigger sample sizes show less benefit of getting vaccinated after already developing natural immunity. https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2
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Re: Wizards Board COVID-19 Thread 

Post#370 » by dckingsfan » Wed Sep 29, 2021 10:30 pm

nate33 wrote:
Kanyewest wrote:People who have natural immunity and aren’t vaccinated are twice as likely to contract COVID as those who’ve been vaccinated (Pre-Delta)

https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.htm

So what?

The naturally immune are still less likely to contract Covid than the vaccinated who have never contracted Covid.

The question was posed earlier - what is the best protection. The answer is both infection + vaccine. This pre-release study makes the point that it could be the case. But one study does not a picture make. I think this, among other studies, warrants a future look into the data in a longitudinal way.

And, it is material from a public policy standpoint. We know that both the vaccines and getting Covid have waning immunity.

1) This information will be material in determining the roll out boosters to those that have had Covid.
2) It may give us clues going forward on the when to give boosters to those that have had Covid.
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Re: Wizards Board COVID-19 Thread 

Post#371 » by dckingsfan » Wed Sep 29, 2021 10:40 pm

nate33 wrote:Also, that Kentucky study has a miniscule sample size. Other studies with bigger sample sizes show less benefit of getting vaccinated after already developing natural immunity. https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2

Here is the actual non-peer reviewed study that you cite:
https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v2

If you read the comments section, you see things like:

I haven't scrutinized this paper but even if all the results are accepted, the one-line "Conclusions" at the beginning is highly problematic without qualifiers. "Unlikely to benefit"? This study is limited, so the conclusion can't be so broad. Are elderly or long-haulers unlikely to benefit? You've got a 42 day window (seems arbitrary) so if you got the disease 6 months prior are you unlikely to benefit from the vaccination? The study doesn't address any of these things, yet makes a huge leap in its conclusion. This is a pre-print so PLEASE make a conclusion that fits your experiment and data. Because it's likely the only thing the general public will read and it will become the basis for more misinformation.


I think that since we have contradictory studies (not just this one and the one before), it is worthwhile to do the longitudinal work.
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Re: Wizards Board COVID-19 Thread 

Post#372 » by Ruzious » Thu Sep 30, 2021 12:22 am

Just wondering - Is there a test to show whether or not you've had Covid in the past? I'm sure I'm like a lot of people who have had some of the milder symptoms and would guess that I never got it - but really don't know.
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Re: Wizards Board COVID-19 Thread 

Post#373 » by Kanyewest » Thu Sep 30, 2021 2:14 am

nate33 wrote:
Kanyewest wrote:People who have natural immunity and aren’t vaccinated are twice as likely to contract COVID as those who’ve been vaccinated (Pre-Delta)

https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.htm

So what?

A jogger wearing a helmet is less likely to fall and crack his skull than a jogger without a helmet, but that doesn't mean we should mandate helmets on all joggers. The point is, a jogger is at very low risk of cracking his skull with or without the helmet. Just like a naturally immune person has a very low risk of being reinfected with a serious case of Covid with or without the vaccine.

Also, that Kentucky study has a miniscule sample size. Other studies with bigger sample sizes show less benefit of getting vaccinated after already developing natural immunity. https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2


The jogger is only putting himself in jeopardy not anyone else- that's not how Covid works. Plus I would be interested in the studies that cite how many head injuries joggers actually have. I fell down a couple of years ago jogging- not much happened.

I agree the data isn't great but it does outlie a hypothesis that getting vaccinated is safer than getting Covid and not. Even Trump got vaccinated after getting Covid.
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Re: Wizards Board COVID-19 Thread 

Post#374 » by Kanyewest » Thu Sep 30, 2021 2:16 am

Ruzious wrote:Just wondering - Is there a test to show whether or not you've had Covid in the past? I'm sure I'm like a lot of people who have had some of the milder symptoms and would guess that I never got it - but really don't know.


There is an antibody test- although the CDC at this time doesn't currently recommend taking the test to decide whether or not you need to be vaccinated.

https://www.cdc.gov/coronavirus/2019-ncov/testing/serology-overview.html
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Re: Wizards Board COVID-19 Thread 

Post#375 » by Kanyewest » Thu Sep 30, 2021 2:23 am

Beal said he was waiting for the 60 day time period to get vaccinated. That is actually the current recommendation by WebMD.

https://www.webmd.com/coronavirus-in-context/video/vaccination-after-infection

That being said, his wife appears to be opposed to vaccines, so it remains a toss up if he will get vaccinated.

I found it interesting that Tatum, who had CoVid, Beal's good friend from St. Louis, got vaccinated but Beal did not.
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Re: Wizards Board COVID-19 Thread 

Post#376 » by nate33 » Thu Sep 30, 2021 4:34 am

Kanyewest wrote:
nate33 wrote:
Kanyewest wrote:People who have natural immunity and aren’t vaccinated are twice as likely to contract COVID as those who’ve been vaccinated (Pre-Delta)

https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.htm

So what?

A jogger wearing a helmet is less likely to fall and crack his skull than a jogger without a helmet, but that doesn't mean we should mandate helmets on all joggers. The point is, a jogger is at very low risk of cracking his skull with or without the helmet. Just like a naturally immune person has a very low risk of being reinfected with a serious case of Covid with or without the vaccine.

Also, that Kentucky study has a miniscule sample size. Other studies with bigger sample sizes show less benefit of getting vaccinated after already developing natural immunity. https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2


The jogger is only putting himself in jeopardy not anyone else- that's not how Covid works. Plus I would be interested in the studies that cite how many head injuries joggers actually have. I fell down a couple of years ago jogging- not much happened.

I agree the data isn't great but it does outlie a hypothesis that getting vaccinated is safer than getting Covid and not. Even Trump got vaccinated after getting Covid.

A naturally immune person is not putting anybody at risk. Naturally immune people are really the only ones that don't transmit Covid because, unlike vaccination, natural immunity is sterilizing immunity.
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Re: Wizards Board COVID-19 Thread 

Post#377 » by Kanyewest » Thu Sep 30, 2021 5:27 am

nate33 wrote:
Kanyewest wrote:
nate33 wrote:So what?

A jogger wearing a helmet is less likely to fall and crack his skull than a jogger without a helmet, but that doesn't mean we should mandate helmets on all joggers. The point is, a jogger is at very low risk of cracking his skull with or without the helmet. Just like a naturally immune person has a very low risk of being reinfected with a serious case of Covid with or without the vaccine.

Also, that Kentucky study has a miniscule sample size. Other studies with bigger sample sizes show less benefit of getting vaccinated after already developing natural immunity. https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2


The jogger is only putting himself in jeopardy not anyone else- that's not how Covid works. Plus I would be interested in the studies that cite how many head injuries joggers actually have. I fell down a couple of years ago jogging- not much happened.

I agree the data isn't great but it does outlie a hypothesis that getting vaccinated is safer than getting Covid and not. Even Trump got vaccinated after getting Covid.

A naturally immune person is not putting anybody at risk. Naturally immune people are really the only ones that don't transmit Covid because, unlike vaccination, natural immunity is sterilizing immunity.


Hard to say that definitively. This is the prevalent thinking that was discussed to me by a scientist earlier today.


The problem is, it's very variable. And by that, I mean you could have had a mild case of COVID and may not have developed many antibodies. Or you might have got it early on, before the Delta variant existed. And you may not have protection against that variant.

What we do know with the vaccines, is they give a much more durable and stronger response. What do I mean by that? It means the response is creating more antibodies than if you just got COVID and developed antibodies and protection. They also last longer, probably at least six months, whereas natural immunity, when you get it from COVID-- that could just be a couple of months.


https://www.webmd.com/coronavirus-in-context/video/vaccination-after-infection

Basically if you had very strong symptoms, then you are more likely to get natural immunity. But according to WebMD, there is a good possibility it may not be as long lasting as the vaccine whereas others will disagree with this point as the scientific consensus is evolving.
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Re: Wizards Board COVID-19 Thread 

Post#378 » by Kanyewest » Thu Sep 30, 2021 5:47 am

One of my friends said he had Covid and was really sick in February/March. However, he never did get tested and never received a positive test, so there's a good possibility that he had the flu given that he didn't lose his sense of taste. He didn't decide to get the vaccine, claiming he has natural immunity.
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Re: Wizards Board COVID-19 Thread 

Post#379 » by nate33 » Thu Sep 30, 2021 1:10 pm

Kanyewest wrote:
nate33 wrote:
Kanyewest wrote:
The jogger is only putting himself in jeopardy not anyone else- that's not how Covid works. Plus I would be interested in the studies that cite how many head injuries joggers actually have. I fell down a couple of years ago jogging- not much happened.

I agree the data isn't great but it does outlie a hypothesis that getting vaccinated is safer than getting Covid and not. Even Trump got vaccinated after getting Covid.

A naturally immune person is not putting anybody at risk. Naturally immune people are really the only ones that don't transmit Covid because, unlike vaccination, natural immunity is sterilizing immunity.


Hard to say that definitively. This is the prevalent thinking that was discussed to me by a scientist earlier today.


The problem is, it's very variable. And by that, I mean you could have had a mild case of COVID and may not have developed many antibodies. Or you might have got it early on, before the Delta variant existed. And you may not have protection against that variant.

What we do know with the vaccines, is they give a much more durable and stronger response. What do I mean by that? It means the response is creating more antibodies than if you just got COVID and developed antibodies and protection. They also last longer, probably at least six months, whereas natural immunity, when you get it from COVID-- that could just be a couple of months.


https://www.webmd.com/coronavirus-in-context/video/vaccination-after-infection

Basically if you had very strong symptoms, then you are more likely to get natural immunity. But according to WebMD, there is a good possibility it may not be as long lasting as the vaccine whereas others will disagree with this point as the scientific consensus is evolving.

They were saying that from the beginning, but we have data now that shows that natural immunity fades much slower than vaccinated immunity.

What happens is, the vaccination gives you a massive amount of antibody titers early on - way more than is necessary to fight Covid. But the antibody level decays rapidly, at about 40% a month. Meanwhile, natural immunity starts off at a lower level, decays slowly, then the decay almost totally stops.

You only need about 50 AU/ml to fight off Covid (best guess, people are different). The vaccine gave recipients an average of a whopping titer level of 12153 AU/ml in the first month. But that level decays by about 40% a month to 6848 in Month 2, then 3476, 2383, 1552, 1122, and 765 by Month 7. Because there's a large standard deviation in those monthly averages, by month 7, 16% of people had an antibody titer level below 50.

Compare that to natural immunity, which only starts you off at a 1914 AU/ml. However, the decay is only 5% a month, dropping to 1739 in Month 2, then 1552, 1195, 1079 by Month 5. It then leveled off in the 800-900 range after than, measuring 860 in Month 6, 904 in Month 7, 850 in Month 8, 901 in Month 9, and 731 in Month 10. Due to the standard deviation, about 10% had a titer level below 50 by Month 4, but that number remained fixed through Month 10, meaning even at Month 10, 90% of participants had a titer level above 50.

Image

https://www.medrxiv.org/content/10.1101/2021.08.19.21262111v1.full.pdf

The bottom line is that vaccination does not appear to give the body a permanent ability to maintain antibody levels - or at least the trend looks that way through 7 months of study. Natural vaccination looks more permanent.

By the way, this study measures, the IgG antibodies in the blood. Those are the ones that prevent serious illness, but don't do much to stop the initial attack (and therefore allow Covid positive people to transmit the virus for several days). The sterilizing antibodies are the IgA antibodies in the mucosa. Vaccines provide virtually none of that. Natural immunity does. The naturally immune are therefore significantly less likely to be spreaders of the virus.

I'll cede that it is possible that an extremely mild initial case of Covid may not produce a significant antibody response. I would expect Beal to test his antibodies before declaring his natural immunity equivalent to vaccination.

The other caveat is this is another "petri dish study". IgG antibodies are not the only facet of immune resistance. One would want to see real world data consistent with this trend before concluding the vaccination immunity fades more quickly. Of course, that is exactly what we are seeing in real life in the countries that vaccinated earliest (Israel, UK, Scotland).
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Re: Wizards Board COVID-19 Thread 

Post#380 » by nate33 » Thu Sep 30, 2021 1:22 pm

dckingsfan wrote:
nate33 wrote:Also, that Kentucky study has a miniscule sample size. Other studies with bigger sample sizes show less benefit of getting vaccinated after already developing natural immunity. https://www.msn.com/en-us/health/medical/people-already-infected-with-covid-19-gain-no-additional-benefits-from-vaccination-study/ar-AAKQba2

Here is the actual non-peer reviewed study that you cite:
https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v2

If you read the comments section, you see things like:

I haven't scrutinized this paper but even if all the results are accepted, the one-line "Conclusions" at the beginning is highly problematic without qualifiers. "Unlikely to benefit"? This study is limited, so the conclusion can't be so broad. Are elderly or long-haulers unlikely to benefit? You've got a 42 day window (seems arbitrary) so if you got the disease 6 months prior are you unlikely to benefit from the vaccination? The study doesn't address any of these things, yet makes a huge leap in its conclusion. This is a pre-print so PLEASE make a conclusion that fits your experiment and data. Because it's likely the only thing the general public will read and it will become the basis for more misinformation.


I think that since we have contradictory studies (not just this one and the one before), it is worthwhile to do the longitudinal work.

I agree. We don't really know enough about the issue. That's why I find it rather surprising that the Kentucky study was trumpeted by the CDC as the justification for requiring naturally immune people to get vaccinated. We already have enough data to prove that natural immunity is better than, or at least roughly equivalent to vaccination immunity for at least 8 months. With that the case, there should be no requirements that naturally immune get vaccinated. Natural immunity should count as equivalent to a vaccination passport until we get further data to prove otherwise.

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