I do wonder how it would hit if you weren't familiar with the movies that came before. I think it's still a good super hero movie, but this was obviously a movie for fans who had seen what came before.
That said, I wouldn't even say I really liked most of the films in the series. I recently watched Spider-man 2 and that one really doesn't hold up anymore. Obviously 3 was terrible. I've only seen random scenes of the Amazing Spider-Man series that might equal the whole two movies if pieced together. I think Tom Holland is a great Spider-man, but I didn't love either of the first two movies at all. Some great moments, but not great movies.
But No Way Home gives you an avalanche of fan service from all those movies to the point where I can't even believe what I'm watching. The story rules and it all somehow actually works. The beats hit perfectly.
I can't wait to see it again.