As usual, the **** moron DDB posts disinformation & demonstrates once again he has the medical insight of a pebble.
Here is something published yesterday suggesting UNIVERSAL BOOSTING superimposed on 2 prior mRNA vaccinations or a previous native Covid infection ‘may’ make a big difference. https://www.medrxiv.org/content/10.1101/2021.12.12.21267646v1.full.pdfOf particular concern, neutralizing antibody titers against Omicron were low, even below the limit of detection in a significant fraction of convalescent individuals, Ad26 vaccine recipients or 2 dose mRNA vaccine recipients, particularly following the waning that ensues following infection or vaccination. Nevertheless, individuals that had been previously infected with SARS- CoV-2 and subsequently received mRNA vaccines, or those that have received THREE doses of mRNA vaccines had substantial neutralizing antibody titers against Omicron ~1 month after boosting. The ability of plasmas from these individuals to neutralize Omicron likely represents the COMBINED effect of increased antibody levels PER SE following multiple exposures to antigen, as well as the effects of ‘affinity maturation’ (‘ADAPTABLE ANTIBODY RESPONSE’ OF PLASMA CELLS TO WILD TYPE ANTIGEN - ANALOGOUS TO THE ‘ADAPTABLE ANTIBODY RESPONSE’ OF MEMORY B CELLS) that can dramatically improve the neutralizing breadth of individual SARS-CoV-2 antibodies as well as polyclonal plasma.
These findings suggest that boosting and promoting ‘affinity maturation’ of the antibodies of those who have previously been infected or vaccinated using existing Wuhan-hu-1 based vaccine immunogens will provide additional protection against Omicron variant infection and disease. The emergence of the Omicron lineage that is phylogenetically distinct from the previously globally dominant Delta SARS-CoV-2 variant also illustrates the need for continuing vigilance and mitigation of virus transmission. The prior emergence, and global spread of the Alpha, Delta, and Omicron variants underscore our inability to predict the emergence of variants that might facilitate targeted vaccine development.
The findings described herein and the emergence of Omicron suggest that effort should be devoted to development of vaccination strategies that are broadly based rather than, or in addition to, those narrowly targeted at contemporary emergent SARS-CoV-2 variants.
The chances of morons like DDB understanding any of this are 1 billion to 1.
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